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Bariatric surgery and incident development of obesity-related comorbidities

This cascade also appears to intersect with mitochondrial and ER stress pathways, where redox imbalance and unfolded protein responses converge-mechanisms mechanistically reminiscent of those implicated in neurodegeneration

Nature medicine 21 , 263269, doi: 10.1038/nm.3804 (2015)

Among these, leptin and APN are pivotal regulators of energy homeostasis and lipid metabolism ( Hyperleptinemia, a hallmark of obesity, induces leptin resistance via diminished hypothalamic sensitivity, perpetuating metabolic disturbances such as IR and cardiovascular disease