tirzepatide once weekly for the treatment of obesity journal club Maintenance Body Weight Reduction: Rationale, Design, and Baseline Characteristics of SURMOUNT‐MAINTAIN - Horn - 2025 New drug tirzepatide delivers significant

Eating smaller, more frequent meals

In both peptides, the N-terminal histidine sits in an enclosed pocket forming hydrophobic and hydrogen bond interactions with E364 6 .53 , E387 7 .42 , R310 5 .40 , Y241 3 .44 , W306 5 .36 , I313 5 .43 and Q234 3 .37 however, these interactions are more persistent with GLP-1, and this is likely linked to the stability of interactions of Glu9 and with residues at the base of the binding cavity (Supplemental Table 3, Supplemental Movie 1)

4EBP1 phosphorylation (eIF4E availability marker) is similarly sustained, predicting enhanced translational capacity consistent with protein synthesis upregulation

What if Im sensitive to medications or worried about side effects