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In studies examining fructoses effects on PCOS, Johnson et al

Serving Size: 1 mL (2 Pumps) Servings Per Container: 50 Amount Per Serving Riboflavin (as Riboflavin-5-Phosphate) 3.6 mg (277%) Niacin (as Niacin, Niacinamide) 10 mg (63%) Vitamin B6 (as Pyridoxine HCl) 6.7 mg (394%) Folate (as Calcium Folinate) 850 mcg DFE (213%) Vitamin B12 (as Methylcobalamin) 500 mcg (20,833%) Biotin 500 mcg (1667%) Pantothenic Acid (as Calcium d-Pantothenate) 22.5 mg (450%) Proprietary Blend 125 mg Phosphatidylcholine (from highly purified phospholipids), Milk Thistle Seed Extract, Trimethylglycine (as Betaine) Other Ingredients: Water, glycerin, ethanol, tocofersolan, EDTA (as preservative), natural flavorings, natural citrus oils, natural mixed tocopherols

That's effective and it also creates predictable challenges

Treatment of rheumatoid arthritis with gammalinolenic acid