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The article says the right move on seeing any of them, or after the stability window the pharmacy specified has passed, is to contact the pharmacy or prescriber before using that vial rather than deciding alone

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[DOI] [PubMed] [Google Scholar] 20.Barati S, Kashani IR, Tahmasebi F

At this concentration, luteolin significantly suppressed phosphorylation of c-Jun at Ser63 and Ser73 residues in nuclear extracts, with no effects on p-Syk, p-Lyn, or p38 MAPK, p44/p42 MAPK, or p54/56 SAPK/JNK in cytoplasmic, or c-Jun in nuclear fractions[170]