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Idebenone improves motor dysfunction, learning and memory by regulating mitophagy in MPTP-treated mice

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Ghrelin strongly stimulates appetite, significantly elevates cortisol, and regulates multiple metabolic and GI functions through GHSR-1a and secondary receptor interactions

Firstly, by dampening inflammatory responses integral to the pathophysiology of depression and anxiety, omega-3 PUFAs and their metabolites can inhibit leukocyte chemotaxis, reduce the expression of adhesion molecules, decrease the production of pro-inflammatory mediators, and encourage a shift in microglia polarization towards a reparative, non-inflammatory state (75, 76)