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However, this group may need to remain on the maximum 12mg dose for the full treatment period to achieve optimal results

While the timeline includes it as part of the combination drug Qsymia (approved in 2012), phentermine on its own was approved by the FDA much earlier, back in 1959, for short-term use (typically up to 12 weeks)

However, they should not be used with DPP-4 inhibitors (such as sitagliptin), and insulin or sulphonylurea doses may need adjustment to prevent hypoglycaemia

These findings provide direct genetic evidence that variation in the drug target genes contributes to inter-person variability in response and lay the foundation for precision medicine approaches in the treatment of obesity